bio-population-genetics-selection-statistics
PKU-YuanGroup/OpenAI4SScans genomes for natural selection with SFS tests (Tajima's D, Fay & Wu H, Zeng E, SweepFinder2 CLR), haplotype tests (iHS, nSL, XP-EHH, Rsb, H12), and…
Scores out of 100 · grade A
2026-08-22Works
40% of the score100/100
- Loads cleanly: valid frontmatter, required fields present, no dangling references.
Maintained
25% of the score100/100
- no commits in the last 12 weeks
Adopted
20% of the score35/100
- 335 stars on the source repo.
Documented
15% of the score100/100
- 2,918 words with worked examples.
- Ships 2 bundled files.
Install
npx skills add PKU-YuanGroup/OpenAI4S/bio-population-genetics-selection-statisticsWhat it says it does
Scans genomes for natural selection with SFS tests (Tajima's D, Fay & Wu H, Zeng E, SweepFinder2 CLR), haplotype tests (iHS, nSL, XP-EHH, Rsb, H12), and differentiation (FST, PBS) using scikit-allel, selscan, and SweepFinder2. No single statistic separates selection from demography at one locus, so the deliverable is empirical genome-wide outliers plus multiple orthogonal signals, not an absolute cutoff. iHS detects incomplete sweeps and collapses to zero at fixation while XP-EHH catches fixed sweeps; iHS/nSL standardize within derived-allele-frequency bins but XP-EHH gets a genome-wide z-score; derived-allele tests need substitution-model polarization; background selection mimics FST and CLR. Use when computing selection statistics like FST, Tajima's D, iHS, or XP-EHH, or scanning for selective sweeps. For phasing inputs see phasing-imputation/haplotype-phasing; for dN/dS see comparative-genomics/positive-selection.
Also in PKU-YuanGroup/OpenAI4S
| Artifact | Score | What the check found | Type | Reach | Last commit |
|---|---|---|---|---|---|
| bio-atac-seq-allele-specific-accessibilityPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today | |
| bio-atac-seq-atac-peak-callingPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today | |
| bio-atac-seq-consensus-peaksetPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today | |
| bio-atac-seq-deep-learning-atacPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today | |
| bio-atac-seq-footprintingPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today | |
| bio-causal-genomics-effector-gene-prioritizationPKU-YuanGroup/OpenAI4S | clean | Skill | 335 stars | today |
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