bio-crispr-screens-combinatorial-screens
lilinji/GeneTind-Life-SkillsDesigns and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer…
Scores out of 100 · grade B+
2026-08-22Works
40% of the score100/100
- Loads cleanly: valid frontmatter, required fields present, no dangling references.
Maintained
25% of the score94/100
- no commits in the last 12 weeks
- no license file
Adopted
20% of the score13/100
- 8 stars on the source repo.
Documented
15% of the score91/100
- 2,300 words with worked examples.
- Ships 2 bundled files.
Install
npx skills add lilinji/GeneTind-Life-Skills/bio-crispr-screens-combinatorial-screensWhat the check found
| Finding | What it means |
|---|---|
| No license | The repository ships no license file, so the reuse terms are unclear. |
What it says it does
Designs and analyzes combinatorial CRISPR screens covering paired-Cas9 (Big Papi, Najm 2018), enhanced AsCas12a multiplex (enCas12a, DeWeirdt 2021), in4mer 4-guide-array Cas12a (Esmaeili Anvar N et al 2024 Nat Commun 15:3577) and the Inzolia paralog-pair library, paralog-buffering detection (Dede 2020 Genome Biol; Thompson 2021 Nat Commun 12:1302), genetic-interaction (GI) scoring as observed_double_LFC minus expected_additive_double_LFC, synthetic-lethal and synthetic-rescue interaction interpretation, the half-of-essentiality buffered by paralogs phenomenon, multiplex screen statistical analysis with MAGeCK MLE interaction terms, and the relationship to single-cell combinatorial Perturb-seq. Use when designing a paralog or pathway-pair screen, choosing between paired-Cas9 (Big Papi) and Cas12a multiplex (Inzolia), interpreting genetic interaction scores, identifying synthetic-lethal targets for drug development, or scaling beyond single-gene CRISPR screens.
Also in lilinji/GeneTind-Life-Skills
| Artifact | Score | What the check found | Type | Reach | Last commit |
|---|---|---|---|---|---|
| arboretolilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today | |
| aws-cdk-developmentlilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today | |
| bidslilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today | |
| adaptyvlilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today | |
| analyze-fastalilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today | |
| ancestry-risk-profilerlilinji/GeneTind-Life-Skills | No license | Skill | 8 stars | today |
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