target-prioritization
Agents365-ai/365-skillsPrioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with…
Scores out of 100 · grade B+
2026-08-14Works
40% of the score86/100
- References 2 files that are not in the repo: targets_summary.csv, targets_report.md.
Maintained
25% of the score86/100
- no commits in the last 12 weeks
- no license file
Adopted
20% of the score44/100
- 1,994 installs on skills.sh.
- 31 stars on the source repo.
Documented
15% of the score100/100
- 1,023 words with worked examples.
- Ships 10 bundled files.
Install
npx skills add Agents365-ai/365-skills/target-prioritizationWhat the check found
| Finding | What it means |
|---|---|
| Missing files | It points at files that are not in the repository, so those steps will fail. |
| No license | The repository ships no license file, so the reuse terms are unclear. |
Files it references that are not in the repository
What it says it does
Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.
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